|
KMID : 0381920060360020057
|
|
Korean Journal of Microscopy
2006 Volume.36 No. 2 p.57 ~ p.72
|
|
|
Protective Effects of Activated Charcoal on the Acute Damages of Kidney of Mouse by Lead
|
|
Cheong Min-Ju
Roh Young-Bok
|
|
|
Abstract
|
|
|
|
A protective effect of activated charcoal against the acute lead poisoning of kidney was studied in mice. Mice approximately 30 gm in weight were grouped into the control, lead acetate-treated, and the activated charcoal-treated after lead acetate groups. Lead acetate (60 mg/kg) and activated charcoal (40 mg/kg) were delivered orally. Serum BUN and creatine were measured and ultrastructural alteration of renal tissues were examined by electron microscopy. Activated charcoal were decreased the increase of serum BUN and Creatinine level induced by lead. Lead acetate-treated renal tissues were characterized by the loss of microvilli in the renal tubule cells, irregular nucleus, enlarged and reduced number of mitochodria, enlarged rough endoplasmic reticulum, loss of ribosomes. Cells treated with activated charcoal were similar to those of the control group. In conclusion, activated charcoal may protect the lead-induced toxicity on kidney.
|
|
|
KEYWORD
|
|
|
Activated Charcoal, Kidney, Lead, Mouse
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|